Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | FABP7 | O15540 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859257 | 0.89 | HTT (0.43) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL6853751 | 0.86 | HTT (0.42) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL6095920 | 0.83 | CCR6 (0.35) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL7752775 | 0.73 | CCR6 (0.52) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL1897393 | 0.72 | CCR6 (0.51) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL4194136 | 0.72 | CCR6 (0.51) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL16585962 | 0.71 | CCR6 (0.60) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL12311314 | 0.70 | PAX8 (0.49) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL17747886 | 0.69 | CCR6 (0.48) | CCR6PAX8ALDH1A1TDP1MAPK1 | |
| SCHEMBL17377997 | 0.69 | CCR6 (0.61) | CCR6PAX8ALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101876-B2 | Substituted benzoxazines as integrin antagonists | PHARMACIA CORPORATION (US) | 2006-09-05 | — | — | US | disclosed |
| US-20040224948-A1 | Novel substituted benzoxazines as integrin antagonists | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-11-11 | — | — | US | disclosed |
| US-6750215-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-06-15 | — | — | US | disclosed |
| US-20030073688-A1 | Novel substituted benzoxazines as integrin antagonists | POLSTER, RACHEL A. | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224948-A1 | Novel substituted benzoxazines as integrin antagonists | ITGB1, ITGA1, ITGB3 | CCR6 2053/4885PAX8 4319/4885ALDH1A1 620/4885 |
| US-20030073688-A1 | Novel substituted benzoxazines as integrin antagonists | ITGB1, ITGA1, ITGB3 | CCR6 2053/4885PAX8 4319/4885ALDH1A1 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.