Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 8/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098231 | 0.87 | HTR7 (0.60) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL31302628 | 0.78 | EPHX1 (0.54) | EPHX1L3MBTL1HTR6BCHE | |
| SCHEMBL31302652 | 0.78 | EPHX1 (0.54) | EPHX1L3MBTL1HTR6BCHE | |
| SCHEMBL6095431 | 0.77 | HTR7 (0.72) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6097068 | 0.76 | HTR7 (0.61) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6095078 | 0.76 | EPHX1 (0.46) | EPHX1L3MBTL1HTR6BCHEACHE | |
| Hydrochloric Acid SCHEMBL6097188 | 0.76 | HTR7 (0.71) | HTR7DRD2HTR1AHTR2AHTR1B | |
| Hydrochloric Acid SCHEMBL6096471 | 0.76 | HTR7 (0.60) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6097242 | 0.74 | HTR7 (0.67) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6096791 | 0.73 | EPHX1 (0.55) | EPHX1L3MBTL1HTR6BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885DRD2 74/4885HTR1A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.