Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31302628 | 0.82 | EPHX1 (0.54) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL31302652 | 0.82 | EPHX1 (0.54) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL21561760 | 0.79 | L3MBTL1 (0.60) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL22013140 | 0.78 | L3MBTL1 (0.62) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| Oxalic Acid SCHEMBL6100151 | 0.78 | HTR6 (0.53) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL1520892 | 0.78 | L3MBTL1 (0.70) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL10088115 | 0.78 | L3MBTL1 (0.74) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL31302664 | 0.76 | L3MBTL1 (0.53) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL12050578 | 0.76 | L3MBTL1 (0.65) | EPHX1L3MBTL1PIM1MARK3MAP4K2 | |
| SCHEMBL23522089 | 0.75 | L3MBTL1 (0.67) | EPHX1L3MBTL1PIM1MARK3MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | EPHX1 3058/4885L3MBTL1 3424/4885PIM1 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.