Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.61 |
| ▸ | HTR2A | P28223 | 6/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | HTR1B | P28222 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6096471 | 0.99 | HTR7 (0.60) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6096737 | 0.85 | HTR1A (0.68) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6095431 | 0.80 | HTR7 (0.72) | HTR7HTR2ADRD2HTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL6097188 | 0.80 | HTR7 (0.71) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6097242 | 0.77 | HTR7 (0.67) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6950516 | 0.77 | HTR1A (0.56) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6095073 | 0.76 | HTR7 (0.54) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6097054 | 0.76 | HTR7 (0.72) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6096997 | 0.76 | HTR7 (0.67) | HTR7HTR2ADRD2HTR1AHTR1B | |
| SCHEMBL6095461 | 0.76 | HTR7 (0.76) | HTR7HTR2ADRD2HTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885HTR2A 12/4885DRD2 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.