Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.68 |
| ▸ | HTR7 | P34969 | 8/20 | 0.68 |
| ▸ | DRD2 | P14416 | 6/20 | 0.68 |
| ▸ | HTR2A | P28223 | 5/20 | 0.68 |
| ▸ | HTR1B | P28222 | 1/20 | 0.68 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097068 | 0.85 | HTR7 (0.61) | HTR1AHTR7DRD2HTR2AHTR1B | |
| Hydrochloric Acid SCHEMBL6096471 | 0.84 | HTR7 (0.60) | HTR1AHTR7DRD2HTR2AHTR1B | |
| SCHEMBL6099239 | 0.78 | DRD2 (0.70) | HTR1AHTR7DRD2HTR2AHTR1B | |
| SCHEMBL6097054 | 0.78 | HTR7 (0.72) | HTR1AHTR7DRD2HTR2AHTR1B | |
| SCHEMBL6095461 | 0.78 | HTR7 (0.76) | HTR1AHTR7DRD2HTR2AHTR1B | |
| SCHEMBL6099630 | 0.77 | HTR7 (0.75) | HTR1AHTR7DRD2HTR2AHTR1B | |
| Hydrochloric Acid SCHEMBL7259012 | 0.77 | ADRA1D (0.82) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL6096060 | 0.77 | DRD2 (0.71) | HTR1AHTR7DRD2HTR2AHTR1B | |
| SCHEMBL6095714 | 0.77 | DRD2 (0.74) | HTR1AHTR7DRD2HTR2AHTR1B | |
| SCHEMBL6095930 | 0.76 | HTR7 (0.88) | HTR1AHTR7DRD2HTR2AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR1A 3/4885HTR7 1/4885DRD2 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.