Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30608097 | 0.79 | IDO1 (0.47) | IDO1TDO2ALDH1A1MAPK1AGXT | |
| SCHEMBL511201 | 0.79 | IDO1 (0.47) | IDO1TDO2ALDH1A1MAPK1AGXT | |
| SCHEMBL6205041 | 0.78 | IDO1 (0.46) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL3319428 | 0.78 | IDO1 (0.46) | IDO1TDO2ALDH1A1MAPK1MAOA | |
| SCHEMBL749481 | 0.77 | IDO1 (0.48) | IDO1TDO2ALDH1A1MAPK1MAOA | |
| SCHEMBL14014456 | 0.77 | IDO1 (0.48) | IDO1TDO2ALDH1A1MAPK1MAOA | |
| SCHEMBL842088 | 0.77 | IDO1 (0.48) | IDO1TDO2ALDH1A1MAPK1MAOA | |
| SCHEMBL3689883 | 0.77 | IDO1 (0.48) | IDO1TDO2ALDH1A1MAPK1MAOA | |
| SCHEMBL5772657 | 0.76 | IDO1 (0.52) | IDO1TDO2ALDH1A1MAPK1MAOA | |
| SCHEMBL13479641 | 0.76 | AOC3 (0.54) | IDO1TDO2ALDH1A1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078565-B2 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM PLC (GB) | 2006-07-18 | — | — | US | disclosed |
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | HCRTR2, HCRTR1, OXTR | IDO1 693/4885TDO2 2220/4885ALDH1A1 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.