SCHEMBL609880

SCHEMBL609880

O=C(c1ccc(F)cc1)c1c(Cl)cccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.54
LMNA P02545 2/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
ALOX12 P18054 1/20 0.50
ATM Q13315 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
LTA4H P09960 1/20 0.48
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
RORC P51449 3/20 0.47
PKM P14618 1/20 0.46
KMT2A Q03164 1/20 0.46
DOT1L Q8TEK3 1/20 0.46
NPC1 O15118 2/20 0.45
MAPT P10636 1/20 0.45
RAB9A P51151 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8956556 0.87 GAA (0.48) GAALMNAALDH1A1HPGDALOX12
SCHEMBL5178136 0.84 NR4A1 (0.51) GAALMNAALDH1A1HPGDALOX12
SCHEMBL11850279 0.83 SRD5A2 (0.56) GAAALDH1A1HPGDCES2CES1
SCHEMBL611393 0.81 MAPK1 (0.59) GAALMNAALDH1A1HPGDCES2
SCHEMBL1042856 0.80 ALDH1A1 (0.59) GAALMNAALDH1A1ATMCES2
SCHEMBL333687 0.80 KMT2A (0.62) LMNAALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL29375774 0.80 KMT2A (0.62) LMNAALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL9726458 0.79 ALDH1A1 (0.67) GAALMNAALDH1A1HPGDCES2
SCHEMBL7266220 0.79 ALDH1A1 (0.60) GAALMNAALDH1A1HPGDATM
SCHEMBL16115199 0.79 ALDH1A1 (0.50) GAALMNAALDH1A1HPGDRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2206547-B1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND PROCESSES FOR THE PRODUCTION OF THE SAME, POLYMERS AND PROTON CONDUCTIVE MEMBRANES OF THESE COMPOUNDS JSR CORP (JP) 2016-03-16 EP disclosed
US-8729219-B2 Polyarylene block copolymer having sulfonic acid group and use thereof JSR CORPORATION (JP) 2014-05-20 US disclosed
EP-1906473-B1 ELECTRODE PASTE FOR USE IN SOLID POLYMER FUEL CELL JSR CORP (JP) 2014-02-12 EP disclosed
US-20130085236-A1 POLYARYLENE BLOCK COPOLYMER HAVING SULFONIC ACID GROUP AND USE THEREOF JSR CORPORATION (JP) 2013-04-04 US disclosed
US-8399148-B2 Varnish for a solid polymer fuel cell JSR CORPORATION (JP) 2013-03-19 US disclosed
EP-1947717-B1 ELECTRODE CATALYST LAYER JSR CORP (JP) 2013-02-13 EP disclosed
US-8309678-B2 Aromatic compound and polyarylene copolymer having nitrogen-containing heterocycle including sulfonic acid group in side chain JSR CORPORATION (JP) 2012-11-13 US disclosed
US-8236206-B2 Electrode catalyst layer JSR CORPORATION (JP) 2012-08-07 US disclosed
US-20120052412-A1 POLYARYLENE BLOCK COPOLYMER HAVING SULFONIC ACID GROUP AND USE THEREOF HONDA MOTOR CO., LTD. (JP) 2012-03-01 US disclosed
EP-2424018-A1 Polyarylene block copolymer having sulfonic acid group and use thereof JSR Corporation (JP) 2012-02-29 EP disclosed
US-20100152308-A1 NOVEL AROMATIC COMPOUND AND POLYARYLENE COPOLYMER HAVING NITROGEN-CONTAINING HETEROCYCLE INCLUDING SULFONIC ACID GROUP IN SIDE CHAIN JSR CORPORATION (JP) 2010-06-17 US disclosed
EP-2154173-A1 NOVEL AROMATIC COMPOUND, AND POLYARYLENE COPOLYMER HAVING NITROGEN-CONTAINING HETEROCYCLIC RING CONTAINING SULFONIC ACID GROUP IN SIDE CHAIN JSR Corporation (JP) 2010-02-17 EP disclosed
US-7658867-B2 Includes anode electrode, cathode electrode, and proton conductive membrane, anode electrode and cathode electrode being disposed on opposite sides of the proton conductive membrane, in which proton conductive membrane includes polyarylene with CO or so2 linkages; workability; superior power generation HONDA MOTOR CO., LTD. (JP) 2010-02-09 US disclosed
US-20090149623-A1 NITROGENATED AROMATIC COMPOUND, PROCESS FOR PRODUCTION OF THE SAME, POLYMER, AND PROTON CONDUCTIVE MEMBRANE JSR CORPORATION (JP) 2009-06-11 US disclosed
US-20090134360-A1 ELECTRODE CATALYST LAYER JSR CORPORATION (JP) 2009-05-28 US disclosed
US-20090130526-A1 ELECTRODE ELECTROLYTE FOR USE IN SOLID POLYMER FUEL CELL JSR CORPORATION (JP) 2009-05-21 US disclosed
EP-1947717-A1 ELECTRODE CATALYST LAYER JSR Corporation (JP) 2008-07-23 EP disclosed
EP-1906473-A1 ELECTRODE ELECTROLYTE FOR USE IN SOLID POLYMER FUEL CELL JSR Corporation (JP) 2008-04-02 EP disclosed
EP-1905791-A1 NITROGENATED AROMATIC COMPOUND, PROCESS FOR PRODUCTION OF THE SAME, POLYMER, AND PROTON CONDUCTIVE MEMBRANE JSR Corporation (JP) 2008-04-02 EP disclosed
US-20070015024-A1 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. 2007-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152308-A1 NOVEL AROMATIC COMPOUND AND POLYARYLENE COPOLYMER HAVING NITROGEN-CONTAINING HETEROCYCLE INCLUDING SULFONIC ACID GROUP IN SIDE CHAIN SCO2, H1-0, H1-10 GAA 3826/4885LMNA 2273/4885ALDH1A1 3492/4885
US-20090149623-A1 NITROGENATED AROMATIC COMPOUND, PROCESS FOR PRODUCTION OF THE SAME, POLYMER, AND PROTON CONDUCTIVE MEMBRANE SCO2, KCNH2, KCNH3 GAA 4285/4885LMNA 2009/4885ALDH1A1 4167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.