Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 6/20 | 0.38 |
| ▸ | IGF1R | P08069 | 4/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.37 |
| ▸ | KIT | P10721 | 4/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.37 |
| ▸ | FLT1 | P17948 | 4/20 | 0.37 |
| ▸ | FLT4 | P35916 | 4/20 | 0.37 |
| ▸ | TEK | Q02763 | 4/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094431 | 0.82 | KDR (0.50) | CDK4CCND1KDRKDM4EMAPK1 | |
| SCHEMBL6094987 | 0.78 | MEN1 (0.41) | PDGFRBKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6098483 | 0.78 | MEN1 (0.40) | CDK4CCND1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL6094641 | 0.78 | HTR2A (0.44) | CDK4CCND1EGFRKDRIGF1R | |
| SCHEMBL6095726 | 0.78 | ALDH1A1 (0.44) | CDK4CCND1EGFRKDRIGF1R | |
| SCHEMBL6098311 | 0.77 | F7 (0.43) | ALDH1A1MAPT | |
| SCHEMBL6094956 | 0.77 | ALDH1A1 (0.43) | CDK4CCND1ABL1CDK2GSK3B | |
| SCHEMBL6095976 | 0.75 | TSHR (0.39) | KDRPDGFRBKITKDM4EBRAF | |
| SCHEMBL6095486 | 0.75 | TDO2 (0.46) | CDK4CCND1CDK2 | |
| SCHEMBL6094623 | 0.75 | IMPDH2 (0.45) | CDK4CCND1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7057052-B2 | Heterocyclic quinones as pharmaceutical agents | DUKE UNIVERSITY (US) | 2006-06-06 | — | — | US | disclosed |
| WO-2004050014-A2 | SETEROCYCLIC QUINONES AS PHARMACEUTICAL AGENTS | DUKE UNIVERSITY (US) | 2004-06-17 | — | — | WO | disclosed |
| US-20040063774-A1 | Heterocyclic quinones as pharmaceutical agents | DUKE UNIVERSITY | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063774-A1 | Heterocyclic quinones as pharmaceutical agents | NQO1, RECQL, SDHA | CDK4 106/4885CCND1 183/4885EGFR 4671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.