Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 3/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.55 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | GAPDH | P04406 | 2/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | P2RX6 | O15547 | 1/20 | 0.44 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.44 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.44 |
| ▸ | HRAS | P01112 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099608 | 1.00 | P2RX3 (0.55) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL20938335 | 0.88 | P2RX3 (0.55) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL20938425 | 0.87 | P2RX3 (0.54) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL7110607 | 0.85 | P2RX3 (0.53) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL12352429 | 0.84 | P2RX3 (0.75) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL13169185 | 0.84 | P2RX3 (0.75) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL9189337 | 0.84 | P2RX3 (0.75) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL12243789 | 0.84 | P2RX3 (0.75) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL20141981 | 0.82 | HRAS (0.60) | P2RX3P2RX4P2RX2MEN1USP2 | |
| SCHEMBL20141608 | 0.82 | MEN1 (0.54) | P2RX3P2RX4P2RX2MEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081449-B2 | Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides | VALEANT RESEARCH & DEVELOPMENT (US) | 2006-07-25 | — | — | US | disclosed |
| US-20030144502-A1 | Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides | MDRNA RESEARCH, INC. | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144502-A1 | Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides | DPYD, TYMP, PNPO | P2RX3 162/4885P2RX4 57/4885P2RX2 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.