Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4616116 | 0.93 | NAMPT (0.53) | ALDH1A1POLBTBXAS1NAMPTSMN1; SMN2 | |
| SCHEMBL4619160 | 0.89 | SFRP1 (0.55) | TBXAS1NAMPTSFRP1 | |
| SCHEMBL4619698 | 0.88 | NAMPT (0.49) | TBXAS1NAMPTSFRP1 | |
| SCHEMBL4616582 | 0.85 | ALDH1A1 (0.61) | ALDH1A1POLBTBXAS1SMN1; SMN2SFRP1 | |
| SCHEMBL4617287 | 0.84 | TBXAS1 (0.49) | TBXAS1NAMPTSFRP1 | |
| SCHEMBL4617566 | 0.80 | SFRP1 (0.62) | ALDH1A1POLBTBXAS1NAMPTSMN1; SMN2 | |
| SCHEMBL4618284 | 0.79 | SFRP1 (0.68) | ALDH1A1SFRP1 | |
| SCHEMBL4617473 | 0.78 | TDP1 (0.62) | ALDH1A1SMN1; SMN2SFRP1 | |
| SCHEMBL4617984 | 0.77 | PDE4A (0.52) | ALDH1A1POLBSMN1; SMN2SFRP1 | |
| SCHEMBL4618209 | 0.77 | NAMPT (0.56) | TBXAS1NAMPTSFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ALDH1A1 1865/4885POLB 4876/4885TBXAS1 2485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.