Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | WEE1 | P30291 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | GLI1 | P08151 | 1/20 | 0.39 |
| ▸ | GLI2 | P10070 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4101250 | 0.81 | CHEK1 (0.43) | NQO1PARP1GSK3BCHEK1WEE1 | |
| SCHEMBL1654813 | 0.78 | ALOX5 (0.51) | PARP1GSK3BCHEK1WEE1MEN1 | |
| SCHEMBL11310333 | 0.77 | ERN1 (0.41) | NQO1PARP1GSK3BCASP6MEN1 | |
| SCHEMBL7915346 | 0.76 | GSK3B (0.42) | NQO1PARP1GSK3BCASP6MEN1 | |
| SCHEMBL7278240 | 0.76 | GSK3B (0.44) | PARP1GSK3BCHEK1MEN1KMT2A | |
| SCHEMBL8853099 | 0.75 | KDM4E (0.48) | PARP1GSK3BCHEK1MEN1KMT2A | |
| SCHEMBL11248196 | 0.75 | GSK3B (0.45) | PARP1GSK3BCHEK1WEE1MEN1 | |
| SCHEMBL1756365 | 0.75 | TRPM4 (0.48) | NQO1GSK3BCHEK1MEN1KMT2A | |
| SCHEMBL31241414 | 0.75 | CES1 (0.63) | PARP1GSK3BCASP6MEN1KMT2A | |
| SCHEMBL3079295 | 0.75 | CES1 (0.63) | PARP1GSK3BCASP6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211724-A1 | Hiv integrase inhibitors | VERSCHUEREN GASTON W | 2006-09-21 | — | — | US | claimed |
| US-20060211724-A1 | Hiv integrase inhibitors | VERSCHUEREN GASTON W | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211724-A1 | Hiv integrase inhibitors | SULT1A1, SULT2A1, SULT1E1 | NQO1 611/4885PARP1 1882/4885GSK3B 2237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.