Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6102020 | 0.83 | SFRP1 (0.44) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6102007 | 0.79 | SFRP1 (0.46) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4616255 | 0.77 | KDM4E (0.64) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6103435 | 0.77 | ALDH1A1 (0.50) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4618866 | 0.76 | SFRP1 (0.49) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4619511 | 0.75 | CYP2C19 (0.70) | KDM4EALDH1A1SMN1; SMN2TSHRHTT | |
| SCHEMBL4618025 | 0.74 | ALDH1A1 (0.53) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4616398 | 0.70 | SMN1; SMN2 (0.62) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4616207 | 0.66 | HTR6 (0.50) | POLBKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4618864 | 0.65 | SFRP1 (0.53) | POLBALDH1A1SMN1; SMN2L3MBTL1SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | POLB 4876/4885KDM4E 3044/4885ALDH1A1 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.