Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.84 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.77 |
| ▸ | CNR2 | P34972 | 3/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.70 |
| ▸ | CNR1 | P21554 | 2/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.66 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | PTGES | O14684 | 1/20 | 0.66 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16656482 | 0.89 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL5645575 | 0.88 | AKR1C3 (0.77) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL14086813 | 0.87 | PTGS2 (1.00) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL30426824 | 0.87 | PTGS2 (1.00) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL30761037 | 0.87 | AKR1C3 (0.87) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL1082631 | 0.85 | HIF1A (1.00) | AKR1C3AKR1C2PTGS2HIF1ALMNA | |
| SCHEMBL11458502 | 0.84 | AKR1C3 (0.80) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| Hydrochloric Acid SCHEMBL8646699 | 0.84 | HIF1A (0.98) | AKR1C3AKR1C2PTGS2HIF1ALMNA | |
| SCHEMBL8645594 | 0.83 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2CNR2HIF1A | |
| SCHEMBL10909072 | 0.83 | PTGS2 (0.83) | AKR1C3AKR1C2PTGS2CNR2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089353-A1 | Indole derivative compounds and drugs containing the compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-04-27 | — | — | US | claimed |
| EP-1600440-A1 | INDOLE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-11-30 | — | — | EP | claimed |
| US-20060089353-A1 | Indole derivative compounds and drugs containing the compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-04-27 | — | — | US | disclosed |
| EP-1600440-A1 | INDOLE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089353-A1 | Indole derivative compounds and drugs containing the compounds as the active ingredient | PTGIS, IDO1, IDO2 | AKR1C3 2307/4885AKR1C2 2333/4885PTGS2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.