Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 13/20 | 1.00 |
| ▸ | GSK3B | P49841 | 13/20 | 1.00 |
| ▸ | CCNB2 | O95067 | 11/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 11/20 | 1.00 |
| ▸ | CCNB3 | Q8WWL7 | 11/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6012204 | 0.86 | CDK1 (0.76) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL14499116 | 0.80 | CDK1 (1.00) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL6100749 | 0.75 | CDK1 (0.77) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL15759621 | 0.74 | CDK1 (0.72) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL15270863 | 0.74 | CDK1 (0.60) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL5688237 | 0.71 | GSK3B (1.00) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL12698721 | 0.69 | CA1 (0.80) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| SCHEMBL5688609 | 0.68 | CDK1 (1.00) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| Kenpaullone SCHEMBL79889 | 0.68 | GSK3B (1.00) | CDK1GSK3BCCNB2CCNB1CCNB3 | |
| Kenpaullone SCHEMBL29366756 | 0.68 | GSK3B (1.00) | CDK1GSK3BCCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1580187-A1 | Apoptogenic and antiproliferative analogs of ceramide | Deigner, Hans-Peter (DE) | 2005-09-28 | — | — | EP | claimed |
| US-7232814-B2 | Use of paullone derivatives for making medicines | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2007-06-19 | — | — | US | disclosed |
| US-20060009445-A1 | Tumor-inhibiting anellated azepinone derivatives | FAUSTUS FORSCHUNGS CIE. TRANSLATIONAL CANCER RESEARCH GMBH | 2006-01-12 | — | — | US | disclosed |
| EP-1581534-A2 | TUMOUR-INHIBITING ANNELLATED AZEPINONE DERIVATIVES | Faustus Forschungs Cie. Translational Cancer Research GmbH (DE) | 2005-10-05 | — | — | EP | disclosed |
| EP-1580187-A1 | Apoptogenic and antiproliferative analogs of ceramide | Deigner, Hans-Peter (DE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058766-A2 | TUMOUR-INHIBITING ANNELLATED AZEPINONE DERIVATIVES | FAUSTUS FORSCHUNGS CIE. TRANSLATIONAL CANCER RESEARCH GMBH (DE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009445-A1 | Tumor-inhibiting anellated azepinone derivatives | AZI2, COX15, ERAL1 | CDK1 1156/4885GSK3B 2588/4885CCNB2 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.