Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107190 | 0.92 | PTGER4 (0.44) | ALDH1A1GAANR1H4EPHX2KMT2A | |
| SCHEMBL6106236 | 0.74 | NAMPT (0.45) | NAMPTACACBMMP13LMNAALDH1A1 | |
| SCHEMBL6105680 | 0.74 | MMP13 (0.41) | MMP13LMNAKMT2A | |
| SCHEMBL6184736 | 0.71 | NAMPT (0.42) | NAMPTACACBMMP13LMNAALDH1A1 | |
| SCHEMBL6233299 | 0.69 | NAMPT (0.48) | NAMPTACACBMMP13LMNAGAA | |
| SCHEMBL6230534 | 0.68 | NR1H4 (0.55) | NAMPTACACBMMP13LMNAALDH1A1 | |
| SCHEMBL6106241 | 0.67 | NAMPT (0.42) | NAMPTACACBMMP13LMNAALDH1A1 | |
| SCHEMBL6105402 | 0.67 | PTGER4 (0.46) | MMP13ALDH1A1GAANR1H4EPHX2 | |
| SCHEMBL6104145 | 0.67 | NAMPT (0.41) | NAMPTMMP13LMNAALDH1A1GAA | |
| SCHEMBL6104738 | 0.66 | NAMPT (0.45) | NAMPTMMP13LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132424-B2 | Monocyclic derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040043979-A1 | Monocyclic derivatives as matrix metalloproteinase inhibitors | PICARD JOSEPH ARMAND (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043979-A1 | Monocyclic derivatives as matrix metalloproteinase inhibitors | MMP1, MMP13, MMP9 | NAMPT 2488/4885ACACB 4418/4885MMP13 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.