Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186666 | 0.92 | NR1H4 (0.43) | NR1H4ROCK2RPS6KA5MAP4K4PRKCG | |
| SCHEMBL6184723 | 0.74 | MMP13 (0.39) | MMP13LMNAMEN1HPGDKMT2A | |
| SCHEMBL6105331 | 0.71 | NAMPT (0.44) | NAMPTMMP13GAALMNACYP3A4 | |
| SCHEMBL6188633 | 0.70 | MMP13 (0.46) | MMP13LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6233299 | 0.69 | NAMPT (0.48) | NAMPTMMP13GAALMNACYP3A4 | |
| SCHEMBL6230534 | 0.68 | NR1H4 (0.55) | NAMPTMMP13GAALMNACYP3A4 | |
| SCHEMBL6106236 | 0.68 | NAMPT (0.45) | NAMPTMMP13LMNACYP3A4SMN1; SMN2 | |
| SCHEMBL6106241 | 0.65 | NAMPT (0.42) | NAMPTMMP13LMNACYP3A4SMN1; SMN2 | |
| SCHEMBL6104738 | 0.64 | NAMPT (0.45) | NAMPTMMP13GAALMNACYP3A4 | |
| SCHEMBL6266356 | 0.63 | ALDH1A1 (0.43) | NAMPTGAALMNANR1H4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537098-A1 | MONOCYCLIC DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014892-A1 | MONOCYCLIC DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |