Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.44 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809784 | 0.93 | GFPT1 (0.45) | GFPT1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL5763827 | 0.92 | GAA (0.49) | GFPT1ALDH1A1GAAMAPK1POLB | |
| Trifluoroacetic Acid SCHEMBL6107669 | 0.89 | FKBP1A (0.45) | MAPTFKBP1AGFPT1ALDH1A1KDM4E | |
| SCHEMBL5745153 | 0.88 | FKBP1A (0.48) | MAPTFKBP1AALDH1A1KDM4EGLA | |
| SCHEMBL5767578 | 0.88 | ALDH1A1 (0.48) | MAPTGFPT1ALDH1A1KDM4EGAA | |
| SCHEMBL5768004 | 0.85 | GFPT1 (0.49) | GFPT1KDM4EKMT2A | |
| Trifluoroacetic Acid SCHEMBL5809778 | 0.82 | GFPT1 (0.46) | MAPTGFPT1ALDH1A1KDM4EGAA | |
| Trifluoroacetic Acid SCHEMBL5763821 | 0.80 | GAA (0.51) | MAPTGFPT1ALDH1A1GAAMAPK1 | |
| SCHEMBL5765120 | 0.80 | MEN1 (0.45) | MAPTGFPT1ALDH1A1KDM4EGAA | |
| SCHEMBL5768599 | 0.80 | GFPT1 (0.61) | GFPT1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067529-B2 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-20040259910-A1 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | BOLIN DAVID ROBERT (US) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259910-A1 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | GFPT1, GLS2, GLS | MAPT 1626/4885FKBP1A 2830/4885GFPT1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.