Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 10/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5102304 | 0.97 | RIPK1 (0.38) | RIPK1KDRNPC1RETPDGFRA | |
| SCHEMBL5101380 | 0.93 | KDR (0.39) | RIPK1KDRDGAT1RAB9A | |
| SCHEMBL6375561 | 0.85 | KDR (0.35) | KDR | |
| SCHEMBL1893391 | 0.85 | KDR (0.39) | KDRRETPDGFRA | |
| SCHEMBL5113619 | 0.84 | GCK (0.40) | KDR | |
| SCHEMBL1899097 | 0.84 | KDR (0.38) | KDRRETPDGFRA | |
| SCHEMBL6038526 | 0.83 | RAB9A (0.38) | KDRNPC1HPGDRAB9A | |
| SCHEMBL5107702 | 0.82 | GCK (0.42) | RIPK1KDRABL1 | |
| SCHEMBL5101397 | 0.82 | KDR (0.36) | KDR | |
| SCHEMBL6038768 | 0.82 | SMN1; SMN2 (0.38) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109219-B2 | Nitrogen-containing aromatic derivatives | EISAI CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |