Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15068032 | 0.81 | MCOLN3 (0.45) | JAK2JAK1HSD11B1TSHRHPGD | |
| SCHEMBL6111371 | 0.76 | ALDH1A1 (0.46) | JAK2JAK1HSD11B1ALOX5APFEN1 | |
| SCHEMBL6111003 | 0.76 | HSD11B1 (0.59) | JAK2JAK1HSD11B1ALOX5APFEN1 | |
| SCHEMBL6112269 | 0.76 | HSD11B1 (0.59) | JAK2JAK1HSD11B1ALOX5APFEN1 | |
| SCHEMBL6034241 | 0.74 | PKM (0.58) | PKMTSHRMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6034845 | 0.74 | PKM (0.57) | PKMHTTLMNA | |
| SCHEMBL6035064 | 0.73 | PKM (0.56) | PKMTSHRMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6034697 | 0.72 | USP5 (0.49) | JAK2JAK1HSD11B1TSHRLMNA | |
| SCHEMBL6110503 | 0.72 | TSHR (0.45) | JAK2JAK1HSD11B1TSHRHPGD | |
| SCHEMBL6110740 | 0.72 | GAA (0.50) | HSD11B1TSHRMAPK1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006134481-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 | PFIZER INC. (US) | 2006-12-21 | — | — | WO | disclosed |