Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 3/20 | 0.51 |
| ▸ | DAO | P14920 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316537 | 0.78 | PARP1 (0.46) | ALPLDAOSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL25249969 | 0.78 | ALPL (0.54) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL17279708 | 0.72 | ALPL (0.53) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL6004747 | 0.71 | ALPL (0.46) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL9790418 | 0.70 | ALPL (0.51) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL26111895 | 0.70 | ALPL (0.51) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL30939057 | 0.70 | ALPL (0.44) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL4718005 | 0.69 | DAO (0.44) | ALPLDAOSMN1; SMN2POLBMAPT | |
| SCHEMBL7659167 | 0.68 | PARP1 (0.46) | ALPLDAOPOLBPARP1RAB9A | |
| SCHEMBL17321269 | 0.66 | RAB9A (0.49) | DAOSMN1; SMN2MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006063811-A2 | SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES | BAYER HEALTHCARE AG (DE) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006063813-A2 | 3-ARYLALKYL-SUBSTITUTED AND 3-HETEROARYLALKYL-SUBSTITUTED-1,2,4-TRIAZIN-5(2H)-ONES | BAYER HEALTHCARE AG (DE) | 2006-06-22 | — | — | WO | disclosed |