Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 4/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6112477 | 0.78 | ALPL (0.51) | PARP1ARALDH1A1POLBHTT | |
| SCHEMBL7318428 | 0.77 | PARP1 (0.47) | PARP1HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL7316543 | 0.74 | POLB (0.54) | PARP1HPGDCYP2C9ALDH1A1POLB | |
| SCHEMBL7659167 | 0.74 | PARP1 (0.46) | PARP1POLBALPLDAONPC1 | |
| SCHEMBL11816798 | 0.73 | PARP1 (0.53) | PARP1ARHPGDCYP2C9ALDH1A1 | |
| SCHEMBL6007194 | 0.71 | ALDH1A1 (0.42) | PARP1HPGDALDH1A1POLBMEN1 | |
| SCHEMBL6004747 | 0.71 | ALPL (0.46) | PARP1ALDH1A1POLBALPLDAO | |
| SCHEMBL7325204 | 0.71 | MAPT (0.41) | PARP1ALDH1A1 | |
| SCHEMBL1899895 | 0.70 | NR1H2 (0.58) | PARP1POLBLMNANR1H2NR1H3 | |
| SCHEMBL21634176 | 0.70 | NR1H2 (0.46) | HPGDALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071913-A | 2-(1H-TETRAZOL-5-YL)-4'-(AS-TRIAZIN-YLMETHYL)BIPHENYLS; CARDIOVASCULAR DISEASES, ESPECIALLY HYPERTENSION AND CONGESTIVE HEART FAILURE | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2000-06-06 | — | — | US | disclosed |