SCHEMBL6112976

SCHEMBL6112976

CS(=O)(=O)c1ccc(C#N)cc1F

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 2/20 0.46
EPAS1 Q99814 11/20 0.44
RAD51 Q06609 1/20 0.40
ACLY P53396 1/20 0.40
CCR2 P41597 1/20 0.40
SLC6A9 P48067 1/20 0.39
HSD11B1 P28845 1/20 0.39
VEGFA P15692 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30915553 1.00 TRPV4 (0.46) TRPV4EPAS1RAD51ACLYCCR2
SCHEMBL15412234 0.85 ACLY (0.49) TRPV4EPAS1RAD51ACLY
SCHEMBL30033203 0.81 TRPV4 (0.63) TRPV4EPAS1RAD51ACLYHSD11B1
SCHEMBL30034664 0.81 TRPV4 (0.46) TRPV4EPAS1RAD51ACLY
SCHEMBL12212859 0.81 TRPV4 (0.46) TRPV4RAD51ACLYHSD11B1
SCHEMBL2889391 0.81 TRPV4 (0.63) TRPV4EPAS1RAD51ACLYHSD11B1
SCHEMBL2775587 0.81 TRPV4 (0.46) TRPV4EPAS1RAD51ACLY
SCHEMBL11945262 0.81 TRPV4 (0.43) TRPV4EPAS1RAD51ACLYCCR2
SCHEMBL12966141 0.79 L3MBTL1 (0.53) TRPV4EPAS1RAD51HSD11B1
SCHEMBL6720066 0.78 PTGS2 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118054087-A Electrolyte, electrolyte injection method and lithium metal battery 蜂巢能源科技股份有限公司 2024-05-17 CN claimed
CN-118054087-A Electrolyte, electrolyte injection method and lithium metal battery 蜂巢能源科技股份有限公司 2024-05-17 CN disclosed
US-8754112-B2 Sulfone derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-06-17 US disclosed
US-8754112-B2 Sulfone derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-06-17 US disclosed
US-8754112-B2 Sulfone derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-06-17 US disclosed
EP-2468737-B1 SULFONE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2013-10-30 EP disclosed
EP-2468737-A1 SULFONE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2012-06-27 EP disclosed
US-20120129891-A1 SULFONE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-05-24 US disclosed
US-20120129891-A1 SULFONE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-05-24 US disclosed
US-20120129891-A1 SULFONE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-05-24 US disclosed
WO-2011016470-A1 SULFONE DERIVATIVE 第一三共株式会社 (JP) 2011-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120129891-A1 SULFONE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 TRPV4 2452/4885EPAS1 1318/4885RAD51 4343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.