Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160777 | 1.00 | STAT3 (0.50) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL6113339 | 1.00 | STAT3 (0.50) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL16352686 | 0.88 | STAT3 (0.45) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL18545374 | 0.84 | STAT3 (0.51) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL14731828 | 0.81 | STAT3 (0.49) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL16363921 | 0.81 | STAT3 (0.49) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL14731702 | 0.81 | STAT3 (0.49) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL19361091 | 0.78 | STAT3 (0.46) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL27778249 | 0.77 | ACHE (0.50) | STAT3ACHEESR1ESR2TRPA1 | |
| SCHEMBL6113156 | 0.74 | STAT3 (0.43) | STAT3ACHEESR1ESR2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049723-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS, INC. | 2017-02-23 | — | — | US | claimed |
| US-20160137588-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. | 2016-05-19 | — | — | US | claimed |
| EP-2458983-B1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS INC (US) | 2015-07-08 | — | — | EP | claimed |
| US-20140080916-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS, INC. (US) | 2014-03-20 | — | — | US | claimed |
| EP-2670402-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | Cognition Therapeutics, Inc. (US) | 2013-12-11 | — | — | EP | claimed |
| WO-2012106426-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS, INC. (US) | 2012-08-09 | — | — | WO | claimed |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2012-05-24 | — | — | US | claimed |
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| US-9815770-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-9815770-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-9815770-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| EP-2670402-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | Cognition Therapeutics, Inc. (US) | 2013-12-11 | — | — | EP | disclosed |
| WO-2013029060-A2 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |
| WO-2012106426-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS, INC. (US) | 2012-08-09 | — | — | WO | disclosed |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| WO-2011014880-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | TMEM97, SLC18A2, SIGMAR1 | STAT3 4728/4885ACHE 398/4885ESR1 3137/4885 |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | PSEN2, ACHE, MAPT | STAT3 3872/4885ACHE 2/4885ESR1 4324/4885 |
| US-20170049723-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | APP, MAPT, PSEN1 | STAT3 284/4885ACHE 6/4885ESR1 4310/4885 |
| US-20160137588-A1 | INHIBITORS OF COGNITIVE DECLINE | PSEN2, ACHE, MAPT | STAT3 3872/4885ACHE 2/4885ESR1 4324/4885 |
| US-20140080916-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | APP, MAPT, PSEN1 | STAT3 284/4885ACHE 6/4885ESR1 4310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.