Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 4/20 | 0.46 |
| ▸ | CCKBR | P32239 | 2/20 | 0.45 |
| ▸ | AHR | P35869 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881100 | 0.75 | GPR84 (1.00) | GPR84HTR2ACMA1AHRCA2 | |
| SCHEMBL256689 | 0.70 | GPR84 (0.74) | GPR84HTR2AAHRCA2KEAP1 | |
| SCHEMBL12850750 | 0.70 | GPR84 (0.79) | GPR84HTR2ACMA1AHRCA2 | |
| SCHEMBL9569910 | 0.70 | PTPN1 (0.40) | — | |
| SCHEMBL20548794 | 0.69 | GPR84 (0.71) | GPR84HTR2ACMA1AHRCA2 | |
| SCHEMBL7004405 | 0.69 | HTR2A (0.73) | GPR84HTR2ACA2KEAP1NFE2L2 | |
| SCHEMBL9889542 | 0.68 | HTR2A (0.71) | GPR84HTR2AAHRCA2KEAP1 | |
| SCHEMBL3257855 | 0.67 | GPR84 (0.68) | GPR84HTR2AAHRCA2KEAP1 | |
| SCHEMBL1094688 | 0.67 | GPR84 (0.74) | GPR84HTR2AAHRCA2KEAP1 | |
| SCHEMBL11359977 | 0.66 | HTR2A (0.69) | GPR84HTR2AAHRCA2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323991-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |
| US-8969348-B2 | Chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| US-20120129863-A1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129863-A1 | CHYMASE INHIBITORS | CMA1, CPA3, SERPINB1 | GPR84 3124/4885HTR2A 1756/4885CMA1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.