Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28575405 | 0.88 | SENP7 (0.60) | CHRM1L3MBTL1ADORA1MAPK1LMNA | |
| SCHEMBL6116706 | 0.86 | L3MBTL1 (0.54) | CHRM1L3MBTL1ADORA1MAPK1LMNA | |
| SCHEMBL6116507 | 0.84 | NPSR1 (0.57) | CHRM1L3MBTL1ADORA1MAPK1LMNA | |
| SCHEMBL28575234 | 0.83 | POLB (0.64) | CHRM1ADORA1MAPK1NPSR1POLB | |
| SCHEMBL28576814 | 0.83 | TP53 (0.59) | CHRM1L3MBTL1ADORA1MAPK1LMNA | |
| SCHEMBL18229445 | 0.82 | LMNA (0.71) | CHRM1LMNACNR1CNR2 | |
| SCHEMBL28363587 | 0.81 | HDAC6 (0.65) | HDAC1HDAC2 | |
| SCHEMBL15363130 | 0.80 | L3MBTL1 (0.66) | L3MBTL1ADORA1MAPK1LMNANPSR1 | |
| SCHEMBL28577420 | 0.79 | SLC22A12 (0.72) | L3MBTL1ADORA1MAPK1LMNANPSR1 | |
| SCHEMBL16691696 | 0.79 | TP53 (0.66) | CHRM1LMNAMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130338136-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN INC (US) | 2013-12-19 | — | — | US | disclosed |
| EP-2643297-A1 | INDOLE DERIVATIVES AS MODULATORS OF S1P RECEPTORS | Allergan, Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8530462-B2 | Indole modulators of S1P receptors | ALLERGAN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530462-B2 | Indole modulators of S1P receptors | ALLERGAN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530462-B2 | Indole modulators of S1P receptors | ALLERGAN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| WO-2012071184-A1 | INDOLE DERIVATIVES AS MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012071184-A1 | INDOLE DERIVATIVES AS MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | S1PR1, S1PR3, S1PR2 | CHRM1 684/4885L3MBTL1 4689/4885ADORA1 156/4885 |
| US-20130338136-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | S1PR1, S1PR3, S1PR2 | CHRM1 684/4885L3MBTL1 4689/4885ADORA1 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.