Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | WDR91 | A4D1P6 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23224231 | 0.64 | PTGER4 (0.41) | NAMPTDPP4LMNA | |
| SCHEMBL28380433 | 0.63 | LMNA (0.31) | L3MBTL1MAPTLMNA | |
| SCHEMBL23224234 | 0.62 | NAMPT (0.39) | NAMPTDPP4KDM4ELMNA | |
| SCHEMBL23343882 | 0.62 | POLB (0.43) | ALDH1A1WDR91L3MBTL1MAPTGAA | |
| SCHEMBL13680338 | 0.61 | L3MBTL1 (0.42) | ALDH1A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL20898569 | 0.60 | WDR91 (0.39) | NAMPTALDH1A1WDR91MEN1KMT2A | |
| SCHEMBL20054162 | 0.58 | PTPN1 (0.42) | ALDH1A1KMT2AGAALMNA | |
| SCHEMBL23224236 | 0.57 | NAMPT (0.37) | NAMPTALDH1A1DPP4LMNA | |
| SCHEMBL20738519 | 0.56 | ALDH1A1 (0.57) | ALDH1A1WDR91MAPTKDM4ELMNA | |
| SCHEMBL14045978 | 0.56 | KMT2A (0.51) | ALDH1A1MEN1KMT2AL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640698-A1 | NAMPT AND ROCK INHIBITORS | AbbVie Inc. (US) | 2013-09-25 | — | — | EP | claimed |
| WO-2012067965-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | claimed |
| EP-2640698-A1 | NAMPT AND ROCK INHIBITORS | AbbVie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012067965-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |