Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.30 |
| ▸ | BRD2 | P25440 | 2/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202026 | 0.78 | SMN1; SMN2 (0.38) | LMNAALDH1A1HTTATM | |
| SCHEMBL709488 | 0.77 | LMNA (0.48) | LMNAALDH1A1HTTATMNOTUM | |
| SCHEMBL958691 | 0.75 | BRD4 (0.36) | LMNAALDH1A1HTTATMKAT2B | |
| SCHEMBL103897 | 0.73 | AURKA (0.36) | LMNAALDH1A1HTTATMKAT2B | |
| SCHEMBL31612727 | 0.73 | COMT (0.37) | LMNAALDH1A1HTTNOTUM | |
| SCHEMBL31612726 | 0.73 | COMT (0.37) | LMNAALDH1A1HTTNOTUM | |
| SCHEMBL13729211 | 0.71 | ALDH1A1 (0.36) | LMNAALDH1A1HTTATMKAT2B | |
| SCHEMBL31612733 | 0.69 | THRA (0.34) | LMNAALDH1A1HTTATMKAT2B | |
| SCHEMBL25610036 | 0.69 | HPGD (0.39) | LMNAALDH1A1HTTATMNOTUM | |
| SCHEMBL16037403 | 0.67 | ALDH3A1 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153984-B | Inhibitors of bruton's tyrosine kinase | HOFFMANN LA ROCHE | 2015-04-22 | — | — | CN | disclosed |
| US-8940741-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2015-01-27 | — | — | US | disclosed |
| EP-2603500-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | disclosed |
| US-20130178461-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| US-8481540-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2603500-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-19 | — | — | EP | disclosed |
| CN-103153984-A | Inhibitors of bruton's tyrosine kinase | HOFFMANN LA ROCHE | 2013-06-12 | — | — | CN | disclosed |
| WO-2012020008-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-16 | — | — | WO | disclosed |
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BERTHEL STEVEN JOSEPH (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | LMNA 4654/4885ALDH1A1 4422/4885HTT 4501/4885 |
| US-20130178461-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | LMNA 4654/4885ALDH1A1 4422/4885HTT 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.