Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680179 | 0.89 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL10067534 | 0.82 | ALDH1A1 (0.38) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL3706189 | 0.81 | KDM4E (0.42) | ALDH1A1LMNAKMT2AKDM4ETSHR | |
| SCHEMBL7684740 | 0.81 | POLB (0.37) | HPGDSGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL311179 | 0.80 | KDM4E (0.35) | LMNAKDM4EALOX15TSHRACMSD | |
| SCHEMBL163219 | 0.79 | ABCG2 (0.32) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL5172213 | 0.79 | ABCG2 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7684320 | 0.79 | ALOX15 (0.49) | ALDH1A1LMNAMEN1NPC1GAA | |
| SCHEMBL8647610 | 0.78 | CYP1A2 (0.41) | ALDH1A1MEN1NPC1GAARAB9A | |
| SCHEMBL7456710 | 0.78 | CA12 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188011-B1 | Optimization of ligand affinity for RNA targets using mass spectrometry | ISIS PHARMACEUTICALS, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20050142581-A1 | Microrna as ligands and target molecules | ISIS PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2005023986-A2 | MICRORNA AS LIGANDS AND TARGET MOLECULES | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| EP-1183091-A4 | OPTIMIZATION OF LIGAND AFFINITY FOR RNA TARGETS USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS INC (US) | 2005-03-02 | — | — | EP | disclosed |
| US-6770486-B1 | IDENTIFICATION OF LIGAND COMPOUNDS THAT BIND TO TARGET MOLECULES SUCH AS PROTEINS OR STRUCTURED RNA WITH AS LITTLE AS MILLIMOLAR (MM) AFFINITY USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| US-6359061-B1 | COMBINATORIAL LIBRARIES ARE USEFUL FOR SCREENING IN BIOLOGCAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |
| EP-1183091-A1 | OPTIMIZATION OF LIGAND AFFINITY FOR RNA TARGETS USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2002-03-06 | — | — | EP | disclosed |
| US-6316623-B1 | USEFUL FOR SCREENING IN BIOLOGICAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001058573-A1 | OPTIMIZATION OF LIGAND AFFINITY FOR RNA TARGETS USING MASS SPECTROMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2001-08-16 | — | — | WO | disclosed |