Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129574 | 0.81 | HPGDS (0.34) | MEN1KMT2ALMNAALDH1A1GABRA1 | |
| SCHEMBL7680179 | 0.77 | ALDH1A1 (0.31) | LMNAMAPTALDH1A1HPGD | |
| SCHEMBL9811868 | 0.72 | HSD17B10 (0.32) | LMNAALDH1A1HPGDGABRA1GABRA5 | |
| SCHEMBL7684735 | 0.72 | CYP1A2 (0.36) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL7688968 | 0.69 | CYP2C19 (0.46) | POLBMEN1KMT2ALMNAMAPT | |
| Methyl Alcohol SCHEMBL11407062 | 0.69 | CYP2C19 (0.55) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL621289 | 0.69 | — | — | |
| SCHEMBL10916089 | 0.68 | NPC1 (0.49) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL7684320 | 0.68 | ALOX15 (0.49) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL11405212 | 0.68 | CYP2C19 (0.53) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359061-B1 | COMBINATORIAL LIBRARIES ARE USEFUL FOR SCREENING IN BIOLOGCAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |