Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.60 |
| ▸ | TACR2 | P21452 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SHBG | P04278 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | TST | Q16762 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9808869 | 1.00 | ESR1 (0.60) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL9479954 | 1.00 | ESR1 (0.60) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL9478972 | 1.00 | ESR1 (0.60) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL1133495 | 1.00 | ESR1 (0.60) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL13219975 | 1.00 | ESR1 (0.60) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL3959914 | 1.00 | ESR1 (0.60) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL9324237 | 0.98 | ESR1 (0.57) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL9805784 | 0.93 | RARB (0.56) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL10333376 | 0.93 | RARB (0.56) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL3952158 | 0.92 | CA2 (0.52) | ESR1ADRA2AADORA3TACR2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315735-A4 | PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1315735-A1 | PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS | Merck & Co., Inc. (US) | 2003-06-04 | — | — | EP | disclosed |
| US-6437165-B1 | USEFUL FOR TREATING IMMUNE MEDIATED DISEASES AND CONDITIONS, SUCH AS BONE MARROW, ORGAN AND TISSUE TRANSPLANT REJECTION. | MERCK & CO., INC. | 2002-08-20 | — | — | US | disclosed |
| US-20020091105-A1 | Phosphate derivatives as immunoregulatory agents | MERCK & CO., INC. | 2002-07-11 | — | — | US | disclosed |
| WO-2002018395-A1 | PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS | MERCK & CO., INC. (US) | 2002-03-07 | — | — | WO | disclosed |
| EP-0375350-B1 | Cross-linked vinylpyridinium polymers | SMITH KLINE FRENCH LAB (GB) | 1994-04-20 | — | — | EP | disclosed |
| EP-0370497-B1 | Optically active compound and ferroelectric liquid crystal composition containing the same | ARAKAWA CHEM IND (JP) | 1994-02-16 | — | — | EP | disclosed |
| US-5230885-A | Anticholesterol agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-27 | — | — | US | disclosed |
| US-5209867-A | Spontaneous polarization, ferroelectricity | SHARP KABUSHIKI KAISHA (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0270244-B1 | OPTICALLY ACTIVE ALCOHOLS | CHISSO CORPORATION (JP) | 1991-05-22 | — | — | EP | disclosed |
| EP-0403271-A2 | Polymer compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-12-19 | — | — | EP | disclosed |
| EP-0375350-A2 | Cross-linked vinylpyridinium polymers | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-27 | — | — | EP | disclosed |
| US-4827052-A | Optically active alcohols | CHISSO CORPORATION (JP) | 1989-05-02 | — | — | US | disclosed |
| EP-0270244-A1 | Optically active alcohols | CHISSO CORPORATION (JP) | 1988-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091105-A1 | Phosphate derivatives as immunoregulatory agents | ALPP, PPIP5K2, ALPI | ESR1 4819/4885ADRA2A 3947/4885ADORA3 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.