SCHEMBL6130604

SCHEMBL6130604

Oc1ccc(C(CF)(c2ccc(O)cc2)C(F)(F)F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 12/20 0.54
ESR2 Q92731 11/20 0.54
KIF11 P52732 1/20 0.46
CYP3A4 P08684 3/20 0.41
LMNA P02545 2/20 0.41
TYR P14679 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
AR P10275 1/20 0.41
TSHR P16473 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
HTR6 P50406 1/20 0.41
ESRRG P62508 1/20 0.41
SLC6A3 Q01959 1/20 0.41
SHBG P04278 1/20 0.39
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19401503 0.80 ESR1 (0.56) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL8179562 0.77 KIF11 (0.46) KIF11CYP3A4HPGDTSHRALDH1A1
SCHEMBL16301267 0.77 TSHR (0.42) KIF11CYP3A4LMNATSHRSLC6A4
SCHEMBL10085717 0.77 TSHR (0.42) KIF11CYP3A4LMNATSHRSLC6A4
SCHEMBL3973317 0.76 ESR1 (0.52) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL17266121 0.76 TSHR (0.48) KIF11LMNATSHRALDH1A1CA1
SCHEMBL19401370 0.75 ESR1 (0.47) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL7756496 0.74 ESR1 (0.50) ESR1ESR2KIF11CYP3A4LMNA
SCHEMBL16361644 0.74 ESR1 (0.53) ESR1ESR2AR
SCHEMBL16167930 0.74 CES2 (0.39) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115449008-A Fluorine-containing elastomer, crosslinkable composition, and molded article 大金工业株式会社 2022-12-09 CN disclosed
US-9403925-B2 Curable composition and cured article ADEKA CORPORATION (JP) 2016-08-02 US disclosed
US-9394404-B2 Synthesis and polymerization of oligomeric aliphatic-aromatic based phthalonitriles THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2016-07-19 US disclosed
US-20160168326-A1 SYNTHESIS AND POLYMERIZATION OF OLIGOMERIC ALIPHATIC-AROMATIC BASED PHTHALONITRILES THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2016-06-16 US disclosed
US-9250525-B2 Resist underlayer film-forming composition NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-02-02 US disclosed
US-20150362838-A1 RESIST UNDERLAYER FILM-FORMING COMPOSITION NISSAN CHEMICAL IND LTD (JP) 2015-12-17 US disclosed
US-9112203-B2 Polymer, a method of preparing the same, composite prepared from the polymer, and electrode and composite membrane each including the polymer or the composite SAMSUNG ELECTRONICS CO., LTD. (KR) 2015-08-18 US disclosed
US-8846281-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2014-09-30 US disclosed
US-20140194581-A1 POLYMER, A METHOD OF PREPARING THE SAME, COMPOSITE PREPARED FROM THE POLYMER, AND ELECTRODE AND COMPOSITE MEMBRANE EACH INCLUDING THE POLYMER OR THE COMPOSITE SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) 2014-07-10 US disclosed
US-20140187715-A1 CURABLE COMPOSITION AND CURED ARTICLE ADEKA CORPORATION (JP) 2014-07-03 US disclosed
EP-2749581-A1 CURABLE COMPOSITION AND CURED ARTICLE Adeka Corporation (JP) 2014-07-02 EP disclosed
EP-1444271-A4 FLUORINATED OPTICAL POLYMER COMPOSITION DU PONT (US) 2005-03-02 EP disclosed
US-20040249081-A1 Halogenated optical polymer composition BLOMQUIST ROBERT M (US) 2004-12-09 US disclosed
US-6778753-B2 USED TO FABRICATE PLANAR OPTICAL WAVEGUIDES WITH LOW LOSS AND LOW BIREFRINGENCE E. I. DU PONT DE NEMOURS AND COMPANY 2004-08-17 US disclosed
EP-1444271-A1 FLUORINATED OPTICAL POLYMER COMPOSITION CORNING INCORPORATED (US) 2004-08-11 EP disclosed
US-20030055120-A1 Halogenated optical polymer composition ENABLENCE TECHNOLOGIES USA INC. (CA) 2003-03-20 US disclosed
WO-2003011915-A1 FLUORINATED OPTICAL POLYMER COMPOSITION E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160168326-A1 SYNTHESIS AND POLYMERIZATION OF OLIGOMERIC ALIPHATIC-AROMATIC BASED PHTHALONITRILES AHR, NR4A1, ARNT ESR1 1007/4885ESR2 478/4885KIF11 4566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.