Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bo-653 SCHEMBL5055886 | 0.74 | PTPN1 (0.36) | PTPN1SIRT2TRPV1 | |
| SCHEMBL5479201 | 0.73 | PTPN1 (0.37) | PTPN1SIRT2TRPV1 | |
| SCHEMBL5474064 | 0.73 | PTPN1 (0.37) | PTPN1SIRT2TRPV1 | |
| SCHEMBL5474046 | 0.73 | PTPN1 (0.37) | PTPN1SIRT2TRPV1 | |
| SCHEMBL5471648 | 0.73 | PTPN1 (0.37) | PTPN1SIRT2TRPV1 | |
| SCHEMBL6130778 | 0.72 | ALDH1A1 (0.38) | PTPN1 | |
| SCHEMBL7066288 | 0.69 | AKT1 (0.43) | PTPN1ESR1 | |
| SCHEMBL6767599 | 0.65 | PTPN1 (0.37) | PTPN1SIRT2 | |
| SCHEMBL6130741 | 0.64 | CYP2D6 (0.40) | SIRT2 | |
| SCHEMBL2481913 | 0.64 | CTSB (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050159476-A1 | Pharmaceutical composition for preventing or treating respiratory disease | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-07-21 | — | — | US | disclosed |
| EP-1490048-A4 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2005-06-01 | — | — | EP | disclosed |
| EP-1490048-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082264-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159476-A1 | Pharmaceutical composition for preventing or treating respiratory disease | CFTR, CMA1, SLC5A1 | PTPN1 1800/4885SIRT2 1321/4885TRPV1 1538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.