Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.30 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474064 | 1.00 | PTPN1 (0.37) | PTPN1PTGS2SIRT2TRPV1PTGS1 | |
| SCHEMBL5479201 | 1.00 | PTPN1 (0.37) | PTPN1PTGS2SIRT2TRPV1PTGS1 | |
| SCHEMBL5470101 | 1.00 | PTPN1 (0.37) | PTPN1PTGS2SIRT2TRPV1PTGS1 | |
| SCHEMBL5474046 | 1.00 | PTPN1 (0.37) | PTPN1PTGS2SIRT2TRPV1PTGS1 | |
| Bo-653 SCHEMBL5055886 | 0.99 | PTPN1 (0.36) | PTPN1PTGS2SIRT2TRPV1PTGS1 | |
| SCHEMBL5467048 | 0.95 | PTGS2 (0.32) | PTPN1PTGS2TRPV1PTGS1ALOX5 | |
| SCHEMBL5477593 | 0.90 | CA2 (0.32) | — | |
| SCHEMBL5466692 | 0.84 | HSPA5 (0.36) | — | |
| SCHEMBL5472303 | 0.82 | CA2 (0.33) | — | |
| SCHEMBL5477925 | 0.81 | ALOX5 (0.32) | PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066681-A1 | Pharmaceutical composition for treating fatty liver or hepatic disease | CHUGAI SEIYAKU KAUSHIKI KAISHA (JP) | 2007-03-22 | — | — | US | claimed |
| EP-1666035-A1 | MEDICINAL COMPOSITION FOR TREATMENT FOR FATTY LIVER OR LIVER DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-06-07 | — | — | EP | claimed |
| US-20050159476-A1 | Pharmaceutical composition for preventing or treating respiratory disease | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-07-21 | — | — | US | claimed |
| EP-1490048-A4 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2005-06-01 | — | — | EP | claimed |
| EP-1490048-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082264-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-10-09 | — | — | WO | claimed |
| US-6156793-A | Prophylactic/therapeutic agents for atherosclerosis | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-12-05 | — | — | US | claimed |
| US-6103753-A | ADMINISTERING TO A PATIENT FOR INHIBITING THICKENING OF VASCULAR STENOSIS FOLLOWING PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, A 2,6-DI-T-BUTYLPHENOL DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-08-15 | — | — | US | claimed |
| EP-0982029-A1 | PREVENTIVES/REMEDIES FOR ARTERIOSCLEROSIS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-03-01 | — | — | EP | claimed |
| EP-0868913-A1 | INTIMAL THICKENING INHIBITOR | Chugai Seiyaku Kabushiki Kaisha (JP) | 1998-10-07 | — | — | EP | claimed |
| US-20070066681-A1 | Pharmaceutical composition for treating fatty liver or hepatic disease | CHUGAI SEIYAKU KAUSHIKI KAISHA (JP) | 2007-03-22 | — | — | US | disclosed |
| EP-1666035-A1 | MEDICINAL COMPOSITION FOR TREATMENT FOR FATTY LIVER OR LIVER DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-06-07 | — | — | EP | disclosed |
| CN-1646515-A | Medicinal composition for improving vascular endothelial vascular tone regulation function | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2005-07-27 | — | — | CN | disclosed |
| US-20050159481-A1 | Medicinal composition for improving angiotension-regulating function of blood vessel endothelium | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-07-21 | — | — | US | disclosed |
| EP-1496054-A1 | MEDICINAL COMPOSITION FOR IMPROVING ANGIOTENSION-REGULATING FUNCTION OF BLOOD VESSEL ENDOTHELIUM | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-01-12 | — | — | EP | disclosed |
| US-5663373-A | ANTIISCHEMIC AGENTS AND ANTIOXIDANTS FORMED IN MULTISTAGE REACTION WITH GRIGNARD REAGENT WITH ALDEHYDE, DISSOLVING, ACIDIFICATION, DEPROTECTION AND CYCLIZATION | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-09-02 | — | — | US | disclosed |
| US-5606089-A | ANTIISCHEMIC AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5574178-A | CHEMICAL INTERMEDIATES FOR OXIDATION RESISTANCE AND ANTIISCHEMIC AGENTS FORMED BY MULTISTAGE CYCLIZATION OF ALDEHYDE-ALCOHOL | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1996-11-12 | — | — | US | disclosed |
| CN-1112115-A | 4-alkoxy-2, 6-di-tert-butylphenol derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1995-11-22 | — | — | CN | disclosed |
| EP-0665208-A1 | 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1995-08-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159481-A1 | Medicinal composition for improving angiotension-regulating function of blood vessel endothelium | EDNRA, EDNRB, LIPG | PTPN1 1694/4885PTGS2 190/4885SIRT2 971/4885 |
| US-20050159476-A1 | Pharmaceutical composition for preventing or treating respiratory disease | CFTR, CMA1, SLC5A1 | PTPN1 1800/4885PTGS2 612/4885SIRT2 1321/4885 |
| US-20070066681-A1 | Pharmaceutical composition for treating fatty liver or hepatic disease | LIPC, CPT1A, FABP1 | PTPN1 2790/4885PTGS2 792/4885SIRT2 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.