Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260725 | 0.89 | KDM4E (0.50) | MTNR1AMTNR1BKDM4EPOLBALDH1A1 | |
| SCHEMBL2814704 | 0.87 | CA12 (0.49) | MTNR1AMTNR1BKDM4EPOLBALDH1A1 | |
| SCHEMBL8555827 | 0.87 | MTNR1A (0.56) | MTNR1AMTNR1BKDM4EALDH1A1HPGD | |
| SCHEMBL9209256 | 0.85 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EPOLBALDH1A1 | |
| SCHEMBL6130728 | 0.84 | KDM4E (0.54) | MTNR1AMTNR1BKDM4EPOLBALDH1A1 | |
| SCHEMBL9209251 | 0.82 | MTNR1A (0.45) | MTNR1AMTNR1BKDM4EPOLBALDH1A1 | |
| SCHEMBL10983401 | 0.82 | MTNR1A (0.45) | MTNR1AMTNR1BKDM4EPOLBALDH1A1 | |
| SCHEMBL9220938 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BKDM4EHPGDTDP1 | |
| SCHEMBL1577696 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BKDM4EALDH1A1HPGD | |
| SCHEMBL7956785 | 0.79 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1598065-A2 | Drugs for improving prognosis of brain injury | Japan Science and Technology Agency (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-20050227984-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-13 | — | — | US | disclosed |
| US-20050222235-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | SHIONOGI & CO., LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
| EP-1535629-A1 | DRUGS FOR IMPROVING THE PROGNOSIS OF BRAIN INJURY AND A METHOD OF SCREENING THE SAME | Japan Science and Technology Agency (JP) | 2005-06-01 | — | — | EP | disclosed |
| EP-1334095-B1 | PROCESS FOR THE PREPARATION OF PGD2 ANTAGONIST | SHIONOGI & CO (JP) | 2005-01-19 | — | — | EP | disclosed |
| EP-1334095-A4 | PROCESS FOR THE PREPARATION OF PGD2 ANTAGONIST | SHIONOGI & CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-6693203-B2 | REACTING NOPINONE ENOLATE WITH ALKYL 7-HALO-5-HEPTYNOATE, REACTING PRODUCT WITH HYDROXYLAMINE, TREATING WITH TITANIUM TRICHLORIDE AND BORANE REAGENT, HYDROGENATING, REACTING WITH 5-HYDROXY-4-BENZOTHIOPHENECARBOXYLIC ACID, HYDROLYZING | SHIONOGI & CO., LTD (JP) | 2004-02-17 | — | — | US | disclosed |
| US-20030199702-A1 | Process for the preparation of pgd2 antagonist | LARSEN ROBERT (US) | 2003-10-23 | — | — | US | disclosed |
| EP-1334095-A1 | PROCESS FOR THE PREPARATION OF PGD2 ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-20030027854-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | SHIONOGI & CO., LTD. | 2003-02-06 | — | — | US | disclosed |
| US-6506789-B2 | For prophylaxis and therapy of itching derived from contact dermatitis, allergic conjunctivitis, urticaria, atopic dermatitis | SHIONOGI & CO., LTD. (JP) | 2003-01-14 | — | — | US | disclosed |
| EP-0944614-B1 | BENZOTHIOPHENECARBOXAMIDE DERIVATIVES AND PGD2 ANTAGONISTS COMPRISING THEM | SHIONOGI & CO (JP) | 2002-09-11 | — | — | EP | disclosed |
| US-20020058693-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | ARIMURA AKINORI (JP) | 2002-05-16 | — | — | US | disclosed |
| WO-2002032892-A1 | PROCESS FOR THE PREPARATION OF PGD2 ANTAGONIST | SHIONOGI & CO., LTD (JP) | 2002-04-25 | — | — | WO | disclosed |
| EP-1084711-A1 | REMEDIES FOR ITCHING CONTAINING PGD 2? ANTAGONISTS | SHIONOGI & CO., LTD. (JP) | 2001-03-21 | — | — | EP | disclosed |
| US-6083974-A | BENZOTHIOPHENECARBOXAMIDE CONTAINING NORPINANE RING IS USEFUL FOR PREVENTING NASAL BLOCKAGE | SHIONOGI & CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| EP-0944614-A1 | BENZOTHIOPHENECARBOXAMIDE DERIVATIVES AND PGD2 ANTAGONISTS COMPRISING THEM | SHIONOGI & CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998025919-A1 | BENZOTHIOPHENECARBOXAMIDE DERIVATIVES AND PGD2 ANTAGONISTS COMPRISING THEM | SHIONOGI & CO., LTD. (JP) | 1998-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222235-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | HPGDS, PTGDR, PTGDR2 | MTNR1A 86/4885MTNR1B 84/4885KDM4E 3862/4885 |
| US-20020058693-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | HRH2, PTGER2, PTGDR2 | MTNR1A 80/4885MTNR1B 79/4885KDM4E 4756/4885 |
| US-20030199702-A1 | Process for the preparation of pgd2 antagonist | PTGDR, PTGDR2, PTGER2 | MTNR1A 1023/4885MTNR1B 495/4885KDM4E 1985/4885 |
| US-20030027854-A1 | Methods for the treatment of itching comprising administering PGD2 receptor antagonists | HRH2, PTGER2, PTGDR2 | MTNR1A 80/4885MTNR1B 79/4885KDM4E 4756/4885 |
| US-20050227984-A1 | Drugs for improving the prognosis of brain injury and a method of screening the same | HPGDS, PTGDR, PTGDR2 | MTNR1A 86/4885MTNR1B 84/4885KDM4E 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.