Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD1 | P21728 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | PTPRCAP | Q14761 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130831 | 0.80 | HTR7 (0.52) | DRD2DRD1HTR2AHTR7HTR2C | |
| SCHEMBL6130855 | 0.80 | HTR7 (0.52) | DRD2DRD1HTR2AHTR7HTR2C | |
| SCHEMBL6130877 | 0.80 | KDM4E (0.52) | DRD2DRD1HTR2AHTR7HTR2C | |
| Hydrochloric Acid SCHEMBL3250998 | 0.74 | KDM4E (0.45) | DRD2DRD1HTR2AHTR7HTR2C | |
| SCHEMBL2112127 | 0.72 | LMNA (0.60) | DRD2DRD1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4413729 | 0.72 | LMNA (0.60) | DRD2DRD1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL3250383 | 0.71 | KCNN2 (0.64) | DRD2DRD1HTR2AHTR7HTR2C | |
| SCHEMBL3244548 | 0.71 | KCNN2 (0.60) | DRD2DRD1HTR2AHTR7HTR2C | |
| Hydrochloric Acid SCHEMBL10746848 | 0.71 | LMNA (0.58) | DRD2DRD1KDM4EALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL11099161 | 0.71 | LMNA (0.58) | DRD2DRD1KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971898-B1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | AVERA PHARMACEUTICALS INC (US) | 2005-05-11 | — | — | EP | disclosed |
| EP-1526130-A1 | Substituted isoquinolines as ultra short acting neuromuscular blockers | Avera Pharmaceuticals, Inc. (US) | 2005-04-27 | — | — | EP | disclosed |
| US-6177445-B1 | MUSCLE RELAXANTS | GLAXO WELLCOME INC. | 2001-01-23 | — | — | US | disclosed |