Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.58 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.58 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.58 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31174709 | 0.83 | EPHX2 (0.79) | KDRL3MBTL1EPHX2CACNA1BALDH1A1 | |
| SCHEMBL12077207 | 0.79 | FLT3 (0.76) | KDRFLT3AURKAEPHX2AURKB | |
| SCHEMBL4974321 | 0.78 | EPHX2 (0.70) | KDREPHX2LTA4HKMT2AALDH1A1 | |
| SCHEMBL10132797 | 0.78 | EPHX2 (0.67) | KDRFLT3AURKAEPHX2LTA4H | |
| SCHEMBL29944812 | 0.77 | EPHX2 (0.58) | KDRFLT3AURKAEPHX2AURKB | |
| SCHEMBL6131263 | 0.77 | FFAR1 (0.54) | KDRAURKAEPHX2LTA4HAURKB | |
| SCHEMBL4256144 | 0.77 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL4014247 | 0.76 | EPHX2 (0.79) | EPHX2LTA4HALDH1A1 | |
| SCHEMBL21657710 | 0.76 | HIF1A (1.00) | L3MBTL1HIF1AEPAS1CACNA1BAPBA1 | |
| SCHEMBL3366608 | 0.76 | LTA4H (0.78) | LTA4HALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245518-A1 | Antiproliferative agents | METHYLGENE, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245518-A1 | Antiproliferative agents | HDAC1, HDAC11, HDAC5 | KDR 4081/4885FLT3 2102/4885AURKA 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.