Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | EBP | Q15125 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131988 | 0.90 | DRD3 (0.48) | NPC1RAB9ADRD3ABCB1ADRA1D | |
| SCHEMBL6131991 | 0.90 | DRD3 (0.48) | NPC1RAB9ADRD3ABCB1ADRA1D | |
| SCHEMBL6131974 | 0.85 | NPC1 (0.54) | NPC1RAB9ADRD3ADRA1DADRA1A | |
| SCHEMBL6131794 | 0.81 | ADRA1D (0.68) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6131869 | 0.79 | ADRA1D (0.60) | DRD3ADRA1DADRA1AADRA1BEBP | |
| SCHEMBL6131937 | 0.79 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BEBPSIGMAR1 | |
| SCHEMBL6131777 | 0.79 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BEBPSIGMAR1 | |
| SCHEMBL6131863 | 0.78 | HRH3 (0.51) | NPC1RAB9AHRH3KMT2A | |
| SCHEMBL6131802 | 0.77 | ADRA1D (0.81) | ADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL6131819 | 0.76 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BEBPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |