Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 13/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.35 |
| ▸ | METAP1 | P53582 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489929 | 1.00 | LAP3 (0.46) | LAP3FDPSLMNAGGPS1METAP1 | |
| SCHEMBL6665925 | 0.82 | FDPS (0.50) | LAP3FDPSGGPS1METAP1 | |
| SCHEMBL5262879 | 0.79 | FDPS (0.61) | LAP3FDPSGGPS1 | |
| SCHEMBL5054818 | 0.78 | ANPEP (0.44) | LAP3FDPSLMNAGGPS1ADRB3 | |
| SCHEMBL5054803 | 0.78 | FDPS (0.41) | LAP3FDPSLMNAGGPS1ADRB3 | |
| SCHEMBL28358931 | 0.76 | FDPS (0.41) | LAP3FDPSLMNAADRB3PDE4D | |
| SCHEMBL8591903 | 0.76 | FDPS (0.68) | LAP3FDPSGGPS1 | |
| SCHEMBL28355348 | 0.76 | FDPS (0.41) | LAP3FDPSGGPS1METAP1 | |
| SCHEMBL28440465 | 0.73 | LAP3 (0.43) | LAP3FDPSMETAP1 | |
| SCHEMBL28358933 | 0.73 | FDPS (0.38) | LAP3FDPSLMNAMETAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483283-B1 | Method for the manufacture of aminohydroxy diphosphonic acids | STRAITMARK HOLDING AG (CH) | 2015-01-07 | — | — | EP | disclosed |
| US-8779135-B2 | Method for the manufacture of aminohydroxy diphosphonic acids | STRAITMARK HOLDING AG (CH) | 2014-07-15 | — | — | US | disclosed |
| US-20120245354-A1 | METHOD FOR THE MANUFACTURE OF AMINOHYDROXY DIPHOSPHONIC ACIDS | STRAITMARK HOLDING AG (CH) | 2012-09-27 | — | — | US | disclosed |
| US-7411087-B2 | Process for preparation of bisphosphonic acid compounds | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2008-08-12 | — | — | US | disclosed |
| EP-1605890-A1 | KIT FOR PHARMACEUTICAL USE | The Procter & Gamble Company (US) | 2005-12-21 | — | — | EP | disclosed |
| EP-1539186-A1 | COMBINATION THERAPY COMPRISING A BISPHOSPHONATE AND A HMG-COA REDUCTASE INHIBITOR | Novartis AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004087038-A1 | KIT FOR PHARMACEUTICAL USE | THE PROCTER & GAMBLE COMPANY (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004024165-A1 | COMBINATION THERAPY COMPRISING A BISPHOSPHONATE AND A HMG-COA REDUCTASE INHIBITOR | NOVARTIS AG (CH) | 2004-03-25 | — | — | WO | disclosed |
| EP-1188761-A1 | Novel geminal-diphosphonic acids and their manufacture | SOLVAY (Société Anonyme) (BE) | 2002-03-20 | — | — | EP | disclosed |