Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133755 | 0.85 | CDC7 (0.37) | TGFBR1FBP1ALDH1A1KDM5BCDC7 | |
| SCHEMBL6134226 | 0.84 | ALDH1A1 (0.51) | TGFBR1FBP1ALDH1A1KDM4ECYP1A2 | |
| Bromide SCHEMBL6133333 | 0.83 | ALDH1A1 (0.50) | TGFBR1FBP1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL6134033 | 0.82 | TGFBR1 (0.48) | TGFBR1FBP1ADORA1ALDH1A1KDM4E | |
| SCHEMBL6134156 | 0.81 | TSHR (0.42) | ALDH1A1KDM4EADORA2AMAPTF2RL3 | |
| SCHEMBL6133824 | 0.81 | MAPT (0.39) | TGFBR1FBP1ADORA1ALDH1A1KDM4E | |
| SCHEMBL6133353 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EPTGS2MAPT | |
| SCHEMBL28637603 | 0.79 | ADORA2A (0.46) | TGFBR1FBP1NPY5RADORA1ALDH1A1 | |
| SCHEMBL1255955 | 0.78 | MAPT (0.55) | FBP1ADORA1ALDH1A1KDM4EADORA2A | |
| SCHEMBL6134468 | 0.78 | ADORA2A (0.37) | ADORA1KDM5BCDC7DBF4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | TGFBR1 966/4885FBP1 3420/4885NPY5R 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.