Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.46 |
| ▸ | XIAP | P98170 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133361 | 0.92 | ADORA2A (0.48) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| SCHEMBL6133789 | 0.89 | ALDH1A1 (0.48) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| SCHEMBL6133306 | 0.89 | ADORA1 (0.60) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| SCHEMBL6133290 | 0.88 | ADORA2A (0.58) | ADORA2AADORA1XIAPRORCSMN1; SMN2 | |
| SCHEMBL6133654 | 0.86 | ALDH1A1 (0.54) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| Hydrochloric Acid SCHEMBL6133730 | 0.86 | ADORA2A (0.46) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| Hydrochloric Acid SCHEMBL6134329 | 0.86 | MAPT (0.47) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| Hydrochloric Acid SCHEMBL6134653 | 0.86 | ALDH1A1 (0.45) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| SCHEMBL6135469 | 0.85 | XIAP (0.55) | ALDH1A1ADORA2AADORA1XIAPMAPT | |
| SCHEMBL6133766 | 0.85 | RAB9A (0.46) | ALDH1A1ADORA2AADORA1XIAPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | ALDH1A1 630/4885ADORA2A 635/4885ADORA1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.