Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133356 | 0.92 | KDM4E (0.51) | KDM4EHSD17B10ALOX15TSHRCASP1 | |
| SCHEMBL6134080 | 0.91 | KDM4E (0.53) | KDM4EHSD17B10ALOX15TSHRCASP1 | |
| SCHEMBL6134162 | 0.88 | MEN1 (0.51) | KDM4EALOX15TSHRCASP1SMN1; SMN2 | |
| SCHEMBL6133443 | 0.87 | HSD17B10 (0.50) | KDM4EHSD17B10ALOX15TSHRSMN1; SMN2 | |
| SCHEMBL6133470 | 0.87 | ALDH1A1 (0.47) | KDM4EHSD17B10ALOX15TSHRCASP1 | |
| SCHEMBL6133400 | 0.87 | KDM4E (0.48) | KDM4EHSD17B10ALOX15TSHRCASP1 | |
| SCHEMBL6133851 | 0.86 | HSD17B10 (0.45) | KDM4EHSD17B10TSHRSMN1; SMN2HTT | |
| SCHEMBL6133474 | 0.85 | HTT (0.50) | KDM4EHSD17B10SMN1; SMN2HTTPOLB | |
| SCHEMBL6133697 | 0.85 | HSD17B10 (0.46) | KDM4EHSD17B10SMN1; SMN2HTTTP53 | |
| SCHEMBL6133813 | 0.84 | ALOX15 (0.46) | KDM4EALOX15TSHRCASP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | KDM4E 3814/4885HSD17B10 391/4885ALOX15 1491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.