Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134312 | 0.90 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL6133630 | 0.89 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL6133853 | 0.88 | ADORA2A (0.43) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL6133156 | 0.88 | CNR1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL6133303 | 0.88 | ADORA2A (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6133906 | 0.87 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6133257 | 0.87 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL6133782 | 0.86 | ADORA2A (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL6133654 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL6133159 | 0.85 | ADORA2A (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | NPC1 2391/4885RAB9A 1067/4885SMN1; SMN2 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.