Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.36 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135882 | 0.88 | CES1 (0.56) | CES1MEN1KMT2APOLBS100A4 | |
| SCHEMBL487827 | 0.88 | POLB (0.48) | CES1MEN1KMT2APOLBS100A4 | |
| SCHEMBL29402307 | 0.88 | CES1 (0.56) | CES1MEN1KMT2APOLBS100A4 | |
| SCHEMBL29172805 | 0.85 | CES1 (0.54) | CES1MEN1KMT2APOLBS100A4 | |
| SCHEMBL28503423 | 0.85 | POLB (0.46) | CES1MEN1KMT2APOLBS100A4 | |
| Acetonitrile SCHEMBL29009230 | 0.76 | CES1 (0.45) | CES1MEN1KMT2APOLBS100A4 | |
| Acetic Acid SCHEMBL7085107 | 0.76 | LMNA (0.50) | CES1MEN1KMT2APOLBCASP3 | |
| SCHEMBL8045796 | 0.73 | CES1 (0.47) | CES1MEN1KMT2APOLBS100A4 | |
| SCHEMBL22651544 | 0.73 | DPP4 (0.43) | CES1MEN1KMT2APOLBS100A4 | |
| SCHEMBL10724958 | 0.73 | CES1 (0.47) | CES1MEN1KMT2APOLBS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363516-B1 | AN IMPROVED PROCESS FOR PREPARING SIMVASTATIN | CHONG KUN DANG PHARM CORP (KR) | 2005-08-31 | — | — | EP | disclosed |
| US-6833461-B2 | Process for preparing simvastatin | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2004-12-21 | — | — | US | disclosed |
| US-20040068123-A1 | Process for preparing simvastatin | CHONG KUN DANG PHARMACUETICAL CORP. (KR) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068123-A1 | Process for preparing simvastatin | HMGCR, CETP, MTTP | CES1 94/4885MEN1 1533/4885KMT2A 2224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.