Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6577686 | 0.95 | CA4 (0.39) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL27936584 | 0.95 | CA1 (0.50) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL75144 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL18005921 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL30031849 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL10389404 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL5359209 | 0.94 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL7731758 | 0.91 | CA1 (0.36) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL10697570 | 0.89 | CA1 (0.56) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL455731 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092690-B1 | Method of producing a cement with reduced content of chromium | POVAZSKA CEMENTAREN AS (SK) | 2005-07-13 | — | — | EP | claimed |
| EP-1092690-A1 | Method of producing a cement with reduced content of chromium | Povazská cementáren, a.s. (SK) | 2001-04-18 | — | — | EP | claimed |
| CN-110395726-B | Purification method of microcrystalline graphite ore | 湖南有色金属研究院 | 2021-03-16 | — | — | CN | disclosed |