Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974628 | 0.83 | KMT2A (0.53) | TDP1CRHBPCRHR2KIF18AKMT2A | |
| SCHEMBL28391943 | 0.81 | TDP1 (0.81) | TDP1TSHRMAPK1GPR35VCAM1 | |
| SCHEMBL9138187 | 0.77 | KMT2A (0.41) | TDP1CRHBPCRHR2KIF18AKMT2A | |
| SCHEMBL30821752 | 0.76 | KIF18A (0.64) | KIF18ATSHRMAPK1VCAM1 | |
| SCHEMBL2062571 | 0.76 | MAPK1 (0.58) | KIF18AKMT2ATSHRMAPK1MEN1 | |
| SCHEMBL2768289 | 0.76 | TDP1 (0.60) | TDP1CRHBPCRHR2TSHRMAPK1 | |
| SCHEMBL1052777 | 0.76 | KIF18A (0.64) | KIF18ATSHRMAPK1VCAM1 | |
| SCHEMBL140100 | 0.74 | TDP1 (0.53) | TDP1KIF18AKMT2ATSHRMEN1 | |
| SCHEMBL278488 | 0.73 | TDP1 (1.00) | TDP1TSHRMAPK1CA1CA2 | |
| SCHEMBL17278 | 0.72 | KMT2A (0.70) | TDP1KMT2AMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261329-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1261329-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001068033-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |