Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039256 | 0.86 | LMNA (0.38) | L3MBTL1LMNANPSR1MAPTNPC1 | |
| SCHEMBL6137022 | 0.77 | HSD17B10 (0.56) | HSD17B10NPSR1CXCL8CHRM1CAMK2A | |
| SCHEMBL10896825 | 0.76 | CA2 (0.49) | L3MBTL1HSD17B10LMNANPSR1MAPT | |
| SCHEMBL6136980 | 0.76 | CXCL8 (0.36) | MAPTCXCL8CAMK2AALDH1A1CYP2C9 | |
| SCHEMBL10894946 | 0.70 | GAA (0.46) | L3MBTL1HSD17B10LMNAMAPTNPC1 | |
| SCHEMBL6137045 | 0.70 | HSD17B10 (0.39) | HSD17B10LMNAMAPTNPC1RAB9A | |
| SCHEMBL4900831 | 0.69 | CXCL8 (0.50) | CXCL8CAMK2ACYP2C9CLIC1CLCN2 | |
| SCHEMBL10622242 | 0.68 | HSD17B10 (0.53) | HSD17B10NPSR1MAPTCXCL8CAMK2A | |
| SCHEMBL6540729 | 0.68 | KDM4E (0.45) | HSD17B10LMNARAB9ACAMK2AALDH1A1 | |
| SCHEMBL6137059 | 0.68 | CXCL8 (0.35) | CXCL8CAMK2AALDH1A1CYP2C9CLIC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011651-B1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1011651-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | Merck & Co., Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-1011651-A4 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6020382-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-5847008-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997027847-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | disclosed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | disclosed |