Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137355 | 0.86 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL28437809 | 0.83 | GAA (0.61) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL6137231 | 0.82 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL6137171 | 0.80 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL26664883 | 0.80 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1HTTLMNASMN1; SMN2 | |
| SCHEMBL4755334 | 0.80 | MAPK14 (0.48) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL6137173 | 0.79 | AR (0.57) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL6137339 | 0.78 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL8917192 | 0.78 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1HTTGAALMNA | |
| SCHEMBL6137255 | 0.78 | SMN1; SMN2 (0.56) | ALDH1A1L3MBTL1HTTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372657-A4 | A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1372657-A2 | A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS | Bristol-Myers Squibb Company (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002078639-A2 | A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |