Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | FNTA | P49354 | 2/20 | 0.55 |
| ▸ | FNTB | P49356 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137171 | 0.87 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL6137339 | 0.85 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL6137255 | 0.84 | SMN1; SMN2 (0.56) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL6137213 | 0.82 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL6137355 | 0.81 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL8928263 | 0.81 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL8928258 | 0.80 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL10377682 | 0.78 | KDM4E (0.58) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL9779236 | 0.78 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 | |
| SCHEMBL9779447 | 0.77 | SMN1; SMN2 (0.45) | ALDH1A1L3MBTL1SMN1; SMN2GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372657-A4 | A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1372657-A2 | A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS | Bristol-Myers Squibb Company (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002078639-A2 | A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |