Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.53 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.53 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.53 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.53 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918577 | 0.89 | ALDH1A1 (0.72) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL8918613 | 0.89 | GAA (0.68) | ALDH1A1KDM4EHPGDKMT2AL3MBTL1 | |
| SCHEMBL8917637 | 0.86 | CACNB4 (0.54) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL6137355 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL6137213 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL22573316 | 0.77 | KDM4E (0.76) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL6137173 | 0.75 | AR (0.57) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL32688181 | 0.75 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL31442597 | 0.74 | SMN1; SMN2 (0.81) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL8975579 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670525-A | Substituted 4-phenyl-6-amino-nicotinic acid compounds useful in the treatment of CNS disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | claimed |
| EP-0705820-A1 | 6-Amino-nicotinic acid derivatives and their use as selective K-channel modulators | BAYER AG (DE) | 1996-04-10 | — | — | EP | claimed |
| US-5670525-A | Substituted 4-phenyl-6-amino-nicotinic acid compounds useful in the treatment of CNS disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0705820-A1 | 6-Amino-nicotinic acid derivatives and their use as selective K-channel modulators | BAYER AG (DE) | 1996-04-10 | — | — | EP | disclosed |