SCHEMBL6137239

SCHEMBL6137239

CC1=C(C#N)C(c2ccccc2F)NC(=O)N1C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.43
KDM4E B2RXH2 3/20 0.43
THRB P10828 1/20 0.43
GAA P10253 5/20 0.43
TSHR P16473 4/20 0.42
ALOX15 P16050 4/20 0.41
PKM P14618 1/20 0.40
MAPT P10636 5/20 0.40
GFER P55789 1/20 0.40
CACNA1B Q00975 1/20 0.40
APBA1 Q02410 1/20 0.40
KMT2A Q03164 2/20 0.39
ELANE P08246 2/20 0.37
EEF2K O00418 1/20 0.37
HSD17B10 Q99714 3/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
HPGD P15428 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6610339 0.88 ALDH1A1 (0.41) ALDH1A1KDM4EGAATSHRALOX15
SCHEMBL6137166 0.83 KMT2A (0.45) ALDH1A1GAATSHRKMT2AELANE
SCHEMBL6137190 0.81 LMNA (0.42) ALDH1A1KDM4ETSHRALOX15KMT2A
SCHEMBL6137178 0.80 ELANE (0.43) ALDH1A1KDM4EGAAMAPTKMT2A
SCHEMBL6137082 0.79 TDP1 (0.50) ALDH1A1PKMMAPTKMT2AELANE
SCHEMBL6137123 0.77 TP53 (0.44) ALDH1A1KDM4EALOX15MAPTKMT2A
SCHEMBL6137118 0.74 HTT (0.43) ALDH1A1TSHRMAPTELANECYP2C9
SCHEMBL6608090 0.74 MAPK1 (0.44) ALDH1A1KDM4ETSHRALOX15MAPT
SCHEMBL6608283 0.74 ELANE (0.40) ALDH1A1KDM4EGAAALOX15MAPT
SCHEMBL6137331 0.74 ELANE (0.57) ALDH1A1PKMMAPTKMT2AELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1373221-A4 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL MYERS SQUIBB CO (US) 2004-09-29 EP claimed
EP-1373221-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES Bristol-Myers Squibb Company (US) 2004-01-02 EP claimed
WO-2002079149-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO claimed
EP-1372657-A4 A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2005-11-09 EP disclosed
EP-1373221-A4 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL MYERS SQUIBB CO (US) 2004-09-29 EP disclosed
EP-1372657-A2 A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS Bristol-Myers Squibb Company (US) 2004-01-02 EP disclosed
EP-1373221-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES Bristol-Myers Squibb Company (US) 2004-01-02 EP disclosed
WO-2002079149-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO disclosed
WO-2002078639-A2 A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO disclosed